Magyar Epidemiológiai Társaság
Főoldal Magyar Epidemiológia Közlemények, írások Letöltések Rendezvényeink Ajánlott oldalak Hírek 2017.11.21.
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Magyar Epidemiológia
Közlemények, írások
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Rendezvényeink
Ajánlott oldalak
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PROTECTIVE EFFECT OF HERBAL MIXTURE IN ISOPROTERENOL INDUCED MYOCARDIAL INJURY
Abstract: Background: In our present study we tested an over-the-counter product containing a herbal mixture that is presumed to have a CD34+ stem-cell mobilizing/activating effect. Our aim was to investigate whether the mixture decreases artificially induced myocardial infarction. Materials and methods: A Wistar male rat model was used. Myocardial infarction was induced by a single intraperitoneal injection of 120 mg/kg isoproterenol. Animals in the test group were fed ad libitum with food containing the herbal mixture from the 3rd day before the isoproterenol injection to the end of the experiment. The agent's concentration was assessed according to the recommended daily dose based on the weight of the animals. The control group was fed with a standard LATI rat chow equivalent. Blood was drawn 2h, 24h, 5 days and 10 days after the injection and enzyme markers of hypoxic myocardial injury were tested (CK, LDH, cTnT). 24 hours after the administration of isoproterenol CK, cTn and LDH (p<0.05) values were significantly lower in the treated group. In samples taken after 5 days cTn and LDH was significantly lower in the treated group. Echocardiography was performed after 8 weeks to test residual myocardial function. Results: According to our measurements ejection fraction was significantly higher in the treated group, while septal thickness and left ventricular mass were significantly lower than in the control group. Conclusion: It can be concluded that the tested herbal mixture may decrease the size of myocardial infarction, and eight weeks after the isoproterenol treatment we observed better residual global systolic function. Further experiments are needed to elucidate whether the observed advantageous effect is due to the previously proven stem cell mobilizing effect or to its presumed antioxidant capacity.
Magyar Epidemiológia
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